pocrm: Dose Finding in Drug Combination Phase I Trials Using PO-CRM

Provides functions to implement and simulate the partial order continual reassessment method (PO-CRM) of Wages, Conaway and O'Quigley (2011) <doi:10.1177/1740774511408748> for use in Phase I trials of combinations of agents. Provides a function for generating a set of initial guesses (skeleton) for the toxicity probabilities at each combination that correspond to the set of possible orderings of the toxicity probabilities specified by the user.

Version: 0.13
Depends: dfcrm, nnet
Imports: stats
Published: 2021-09-08
DOI: 10.32614/CRAN.package.pocrm
Author: Nolan A. Wages
Maintainer: "Brewer, Ben (arb5mt)" <arb5mt at virginia.edu>
License: GPL-2
NeedsCompilation: no
CRAN checks: pocrm results


Reference manual: pocrm.pdf


Package source: pocrm_0.13.tar.gz
Windows binaries: r-devel: pocrm_0.13.zip, r-release: pocrm_0.13.zip, r-oldrel: pocrm_0.13.zip
macOS binaries: r-release (arm64): pocrm_0.13.tgz, r-oldrel (arm64): pocrm_0.13.tgz, r-release (x86_64): pocrm_0.13.tgz, r-oldrel (x86_64): pocrm_0.13.tgz
Old sources: pocrm archive


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