OncoBayes2: Bayesian Logistic Regression for Oncology Dose-Escalation Trials

Bayesian logistic regression model with optional EXchangeability-NonEXchangeability parameter modelling for flexible borrowing from historical or concurrent data-sources. The safety model can guide dose-escalation decisions for adaptive oncology Phase I dose-escalation trials which involve an arbitrary number of drugs. Please refer to Neuenschwander et al. (2008) <doi:10.1002/sim.3230> and Neuenschwander et al. (2016) <doi:10.1080/19466315.2016.1174149> for details on the methodology.

Version: 0.8-9
Depends: R (≥ 3.5.0)
Imports: methods, Rcpp (≥ 0.12.0), RcppParallel (≥ 5.0.1), rstan (≥ 2.19.3), rstantools (≥ 2.3.1), posterior (≥ 1.4.0), assertthat (≥ 0.2.1), checkmate, Formula, bayesplot (≥ 1.4.0), ggplot2 (≥ 2.2.1), dplyr (≥ 0.8.0), tibble, tidyr (≥ 1.0.0), abind, scales, rlang (≥ 0.3.0), tidyselect, utils, stats, matrixStats
LinkingTo: BH (≥ 1.72.0), Rcpp (≥ 0.12.0), RcppEigen (≥, RcppParallel (≥ 5.0.1), rstan (≥ 2.19.3), StanHeaders (≥ 2.19.0)
Suggests: rmarkdown, knitr, testthat (≥ 2.0.0), mvtnorm, vdiffr, cmdstanr (≥ 0.4.0)
Published: 2023-07-20
DOI: 10.32614/CRAN.package.OncoBayes2
Author: Novartis Pharma AG [cph], Sebastian Weber [aut, cre], Lukas A. Widmer [aut], Andrew Bean [aut], Trustees of Columbia University [cph] (R/stanmodels.R, configure, configure.win)
Maintainer: Sebastian Weber <sebastian.weber at novartis.com>
License: GPL (≥ 3)
NeedsCompilation: yes
SystemRequirements: GNU make, pandoc (>= 1.12.3), pandoc-citeproc, C++17
Additional_repositories: https://mc-stan.org/r-packages/
Materials: NEWS
CRAN checks: OncoBayes2 results


Reference manual: OncoBayes2.pdf
Vignettes: Guiding Oncology Dose-Escalation Trials


Package source: OncoBayes2_0.8-9.tar.gz
Windows binaries: r-devel: OncoBayes2_0.8-9.zip, r-release: OncoBayes2_0.8-9.zip, r-oldrel: OncoBayes2_0.8-9.zip
macOS binaries: r-release (arm64): OncoBayes2_0.8-9.tgz, r-oldrel (arm64): OncoBayes2_0.8-9.tgz, r-release (x86_64): OncoBayes2_0.8-9.tgz, r-oldrel (x86_64): OncoBayes2_0.8-9.tgz
Old sources: OncoBayes2 archive


Please use the canonical form https://CRAN.R-project.org/package=OncoBayes2 to link to this page.